Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22002673 | 0.77 | NLRP3 (0.41) | NLRP3ATMSMN1; SMN2 | |
| SCHEMBL18310647 | 0.76 | HTR2A (0.31) | ATMSMN1; SMN2 | |
| SCHEMBL22002941 | 0.74 | NLRP3 (0.39) | NLRP3ATMSMN1; SMN2 | |
| SCHEMBL26837204 | 0.73 | NLRP3 (0.37) | NLRP3ATMSMN1; SMN2 | |
| SCHEMBL22989746 | 0.73 | SOS1 (0.31) | SOS1 | |
| SCHEMBL29326087 | 0.73 | PNMT (0.40) | — | |
| SCHEMBL24455319 | 0.72 | EIF4A3 (0.32) | — | |
| SCHEMBL30888603 | 0.70 | SOS1 (0.33) | SOS1SMN1; SMN2 | |
| SCHEMBL25196687 | 0.69 | ATM (0.30) | ATMSMN1; SMN2 | |
| SCHEMBL30888595 | 0.69 | L3MBTL1 (0.39) | NLRP3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021027943-A1 | PYRIMIDINOPYRIDAZINONE DERIVATIVE AND MEDICAL USE THEREOF | 正大天晴药业集团南京顺欣制药有限公司 | 2021-02-18 | — | — | WO | disclosed |