Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 2/20 | 0.44 |
| ▸ | KDM4B | O94953 | 2/20 | 0.44 |
| ▸ | KDM5C | P41229 | 2/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288191 | 0.83 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL22989951 | 0.77 | MAPT (0.48) | MAPTALDH1A1LMNAHPGDPPARG | |
| SCHEMBL22989950 | 0.73 | PKM (0.58) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8273298 | 0.70 | HSD17B10 (0.51) | MAPTKMT2AALDH1A1LMNAHPGD | |
| SCHEMBL1691901 | 0.70 | HTT (0.71) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL26853275 | 0.70 | PKM (0.65) | MAPTALDH1A1LMNAHPGDPPARG | |
| SCHEMBL29703247 | 0.69 | TDP1 (0.72) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9027681 | 0.69 | TDP1 (0.72) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL23122092 | 0.69 | HSD17B10 (0.55) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL18548276 | 0.69 | L3MBTL1 (0.51) | MAPTKDM4AKDM4BKDM5CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021027943-A1 | PYRIMIDINOPYRIDAZINONE DERIVATIVE AND MEDICAL USE THEREOF | 正大天晴药业集团南京顺欣制药有限公司 | 2021-02-18 | — | — | WO | disclosed |