Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 13/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.71 |
| ▸ | RAB9A | P51151 | 8/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.71 |
| ▸ | POLB | P06746 | 5/20 | 0.71 |
| ▸ | MITF | O75030 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | PKM | P14618 | 2/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 6/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 10/20 | 0.65 |
| ▸ | RECQL | P46063 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19000706 | 0.86 | HTT (0.77) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL19011761 | 0.84 | HTT (0.71) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL12218257 | 0.84 | HTT (1.00) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL19011793 | 0.84 | HTT (0.71) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL25341629 | 0.83 | NPBWR1 (0.60) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL31174056 | 0.83 | HTT (0.59) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL8963991 | 0.83 | HTT (0.59) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL22989953 | 0.83 | ALDH1A1 (0.52) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL9123380 | 0.83 | HTT (0.72) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL10642561 | 0.83 | RAB9A (1.00) | HTTALDH1A1NPSR1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645964-A1 | HERBICIDAL COMPOSITION. | DOWELANCO (US) | 1995-04-05 | — | — | EP | claimed |
| WO-1994023578-A1 | HERBICIDAL COMPOSITION | DOWELANCO (US) | 1994-10-27 | — | — | WO | claimed |
| JP-6001773-A | — | — | None | — | — | JP | disclosed |
| JP-6001772-A | — | — | None | — | — | JP | disclosed |
| EP-4737457-A1 | POLYSUBSTITUTED MACROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shenzhen Salubris Pharmaceuticals Co., Ltd. (CN) | 2026-05-06 | — | — | EP | disclosed |
| US-20250154139-A1 | PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS | D. E. SHAW RESEARCH, LLC | 2025-05-15 | — | — | US | disclosed |
| CN-119894901-A | Polysubstituted macrocyclic compound, and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2025-04-25 | — | — | CN | disclosed |
| WO-2025002297-A1 | POLYSUBSTITUTED MACROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳信立泰药业股份有限公司 | 2025-01-02 | — | — | WO | disclosed |
| EP-4472624-A2 | PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS | D.E. Shaw Research, LLC (US) | 2024-12-11 | — | — | EP | disclosed |
| CN-118973564-A | Pyridazinone compounds as TRPA1 inhibitors | D·E·萧尔研究有限责任公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118852163-A | Macrocyclic compound containing heteroatoms, and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2024-10-29 | — | — | CN | disclosed |
| EP-0201765-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-09-18 | — | — | EP | disclosed |
| EP-0398293-A1 | Pyridazinone derivatives and compositions for controlling and/or preventing insect pests | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1990-11-22 | — | — | EP | disclosed |
| US-4892947-A | 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| EP-0258391-A1 | USE OF HETEROCYCLIC NITROGEN-CONTAINING COMPOUNDS FOR REDUCING MOISTURE LOSS FROM PLANTS AND INCREASING CROP YIELD | RHONE POULENC NEDERLAND B.V. (NL) | 1988-03-09 | — | — | EP | disclosed |
| WO-1987004321-A2 | USE OF HETEROCYCLIC NITROGEN-CONTAINING COMPOUNDS FOR REDUCING MOISTURE LOSS FROM PLANTS AND INCREASING CROP YIELD | RHONE-POULENC NEDERLANDS B.V. (NL) | 1987-07-30 | — | — | WO | disclosed |
| EP-0201765-A2 | 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-11-20 | — | — | EP | disclosed |
| EP-0014562-B1 | PYRIDAZINES FOR USE IN TREATING FUNGAL INFECTIONS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | Pfizer Limited (GB) | 1983-10-05 | — | — | EP | disclosed |
| EP-0014562-A1 | Pyridazines for use in treating fungal infections, pharmaceutical compositions containing them, and processes for their preparation | Pfizer Limited (GB) | 1980-08-20 | — | — | EP | disclosed |
| US-4002751-A | SLEEP INDUCERS, CNS DEPRESSANTS | SANDOZ, INC. (US) | 1977-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250154139-A1 | PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV5 | HTT 887/4885ALDH1A1 538/4885NPSR1 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.