SCHEMBL22992194

SCHEMBL22992194

CC#Cc1cc(C)c(C2C(=O)CC3(CCN(C(=O)Nc4ncccc4C)CC3)CC2=O)c(C)c1

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 5/20 0.36
RAB9A P51151 2/20 0.36
MAPT P10636 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
NPC1 O15118 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CDK5 Q00535 3/20 0.35
CDK5R1 Q15078 3/20 0.35
NSD2 O96028 2/20 0.35
DYRK1A Q13627 2/20 0.35
KMT2A Q03164 1/20 0.34
HIF1A Q16665 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22992106 0.88 FAAH (0.38) TRPV1ALDH1A1KMT2A
SCHEMBL21344667 0.85 SMN1; SMN2 (0.42) SMN1; SMN2HIF1A
SCHEMBL21343728 0.84 CYP3A4 (0.31) NSD2KMT2A
SCHEMBL21344695 0.83 TRPV1 (0.36) TRPV1NSD2
SCHEMBL22942059 0.83 RAB9A (0.35) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL22992138 0.82 CHRM2 (0.40) SMN1; SMN2ALDH1A1NSD2KMT2A
SCHEMBL22992095 0.82 PIK3CA (0.34) HIF1A
SCHEMBL21344636 0.81 L3MBTL1 (0.44) SMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL24324680 0.81 NPC1 (0.35) RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A
SCHEMBL21344248 0.80 HIF1A (0.32) HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12043599-B2 Herbicidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2024-07-23 US disclosed
EP-3762378-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2022-05-18 EP disclosed
US-20210047274-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-02-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210047274-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 TRPV1 2779/4885RAB9A 1979/4885MAPT 3999/4885
US-12043599-B2 Herbicidal compounds DDT, CBR3, GLRX3 TRPV1 2779/4885RAB9A 1979/4885MAPT 3999/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.