Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1867738 | 0.85 | HRH3 (0.38) | USP2KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL536772 | 0.80 | USP2 (0.50) | USP2KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL2299301 | 0.78 | ALDH1A1 (0.37) | KDM4EALDH1A1TSHRSMN1; SMN2CYP2C9 | |
| SCHEMBL34472404 | 0.72 | USP2 (0.44) | USP2KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL10447084 | 0.72 | HRH3 (0.47) | USP2KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL949341 | 0.70 | HRH3 (0.50) | USP2KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL15415852 | 0.70 | HRH3 (0.36) | USP2KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL24801728 | 0.68 | DRD3 (0.36) | USP2KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL22550897 | 0.68 | ACHE (0.42) | USP2KDM4EALDH1A1GAATSHR | |
| SCHEMBL23273615 | 0.68 | KEAP1 (0.40) | USP2KDM4EALDH1A1HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |