Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124323 | 0.83 | ALDH1A1 (0.42) | ALDH1A1KDM4ECHRM5ADRA2CTSHR | |
| SCHEMBL7124332 | 0.83 | ALDH1A1 (0.42) | ALDH1A1KDM4ECHRM5ADRA2CTSHR | |
| SCHEMBL7578600 | 0.79 | HRH3 (0.39) | ALDH1A1KDM4EKMT2AMEN1CHRM5 | |
| SCHEMBL2299378 | 0.78 | USP2 (0.41) | ALDH1A1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL277482 | 0.76 | LMNA (0.47) | ALDH1A1KMT2AMEN1CHRM5ADRA2C | |
| SCHEMBL1799442 | 0.73 | HRH3 (0.50) | ALDH1A1KDM4EKMT2AMEN1CHRM5 | |
| SCHEMBL7007038 | 0.73 | HRH3 (0.50) | ALDH1A1KDM4EKMT2AMEN1CHRM5 | |
| SCHEMBL348065 | 0.73 | HRH3 (0.50) | ALDH1A1KDM4EKMT2AMEN1CHRM5 | |
| SCHEMBL3553239 | 0.73 | LMNA (0.44) | ALDH1A1KMT2AMEN1CHRM5ADRA2C | |
| SCHEMBL3558131 | 0.70 | HRH3 (0.47) | ALDH1A1KDM4EKMT2AMEN1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |