Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 3/20 | 0.54 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.50 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.50 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.50 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.50 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.50 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.50 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.50 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.50 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.50 |
| ▸ | CACNA2D4 | Q7Z3S7 | 1/20 | 0.50 |
| ▸ | CACNA2D3 | Q8IZS8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16759524 | 0.88 | PDE4B (0.55) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL12003024 | 0.88 | NR1H2 (0.47) | RBP4CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL2272601 | 0.86 | CACNB4 (0.49) | RBP4CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL21723512 | 0.85 | GPR119 (0.48) | RBP4CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL12002938 | 0.83 | ALDH1A1 (0.49) | RBP4CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL2284479 | 0.83 | RBP4 (0.53) | RBP4CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL8064474 | 0.82 | ALDH1A1 (0.47) | RBP4PDE4BMEN1KMT2ACNR1 | |
| SCHEMBL19833905 | 0.81 | RBP4 (0.61) | RBP4MEN1KMT2ACNR1ALDH1A1 | |
| SCHEMBL24792589 | 0.81 | MRGPRX4 (0.48) | RBP4CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL30053308 | 0.81 | MRGPRX4 (0.48) | RBP4CACNB4CACNA1ACACNA1GCACNG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334269-B2 | Carboxamides as inhibitors of voltage-gated sodium channels | AMGEN INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-20130131035-A1 | CARBOXAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2013-05-23 | — | — | US | disclosed |
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131035-A1 | CARBOXAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | CACNA1B, SCN1A, CACNA1I | RBP4 4798/4885CACNB4 79/4885CACNA1A 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.