Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303992 | 0.86 | PIK3CD (0.30) | CYP11B2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL661613 | 0.71 | CYP1A2 (0.43) | — | |
| SCHEMBL16258372 | 0.69 | LMNA (0.37) | — | |
| SCHEMBL663100 | 0.69 | CYP1A2 (0.43) | — | |
| SCHEMBL664932 | 0.66 | PIK3CD (0.36) | CYP11B2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16931070 | 0.60 | NTRK3 (0.39) | — | |
| SCHEMBL6492773 | 0.57 | POLB (0.48) | — | |
| SCHEMBL29841493 | 0.55 | ALDH1A1 (0.43) | — | |
| SCHEMBL28867137 | 0.55 | ALDH1A1 (0.43) | — | |
| SCHEMBL1989330 | 0.54 | ALDH1A1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536733-A1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | Boehringer Ingelheim International GmbH (DE) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011101424-A1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-25 | — | — | WO | disclosed |