Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.34 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30106504 | 0.89 | KDM5A (0.37) | PARP1SCN10ACNR2ACACBFFAR2 | |
| SCHEMBL23010272 | 0.85 | PARP1 (0.39) | PARP1PARP2TNKSPARP14PARP10 | |
| SCHEMBL24773304 | 0.80 | PARP1 (0.36) | PARP1ACACBPARP2TNKSPARP14 | |
| SCHEMBL21323394 | 0.78 | KIF18A (0.40) | SCN10AFFAR2 | |
| SCHEMBL28493669 | 0.77 | CFTR (0.37) | — | |
| SCHEMBL22524695 | 0.76 | FFAR2 (0.34) | PARP1ACACBFFAR2 | |
| SCHEMBL20998571 | 0.75 | NPC1 (0.46) | SCN10A | |
| SCHEMBL21906143 | 0.74 | SCN10A (0.59) | SCN10A | |
| SCHEMBL21906101 | 0.72 | SCN10A (0.53) | SCN10A | |
| SCHEMBL25629244 | 0.72 | SCN10A (0.33) | SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030554-A1 | PROCESS OF MAKING CFTR MODULATORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-02-18 | — | — | WO | disclosed |