SCHEMBL2301248

SCHEMBL2301248

Clc1ccc(OC(Cl)(Cl)Cl)c(Cl)n1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.34
TSHR P16473 1/20 0.34
CRHBP P24387 1/20 0.32
CRHR2 Q13324 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31361182 0.81 SLC1A5 (0.38) CRHBPCRHR2
SCHEMBL2302384 0.81 SLC1A5 (0.38) CRHBPCRHR2
SCHEMBL2303089 0.79 CRHBP (0.31) CRHBPCRHR2
SCHEMBL5431429 0.73 ALDH1A1 (0.44)
SCHEMBL15074924 0.73 CRHBP (0.39) CRHBPCRHR2
SCHEMBL15618608 0.68 CRHBP (0.35) CRHBPCRHR2
SCHEMBL2300990 0.68 CHRNB2 (0.39)
SCHEMBL16094497 0.68 ALDH1A1 (0.41) TSHR
SCHEMBL19012130 0.65 SLC1A5 (0.36) CYP3A4
SCHEMBL31683787 0.65 CYP3A4 (0.43) CYP3A4TSHRCRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2350008-B1 METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES BAYER CROPSCIENCE AG (DE) 2012-09-05 EP disclosed
EP-2350008-B1 METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES BAYER CROPSCIENCE AG (DE) 2012-09-05 EP disclosed
EP-2350008-A1 METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES Bayer CropScience AG (DE) 2011-08-03 EP disclosed
WO-2010040461-A1 METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES BAYER CROPSCIENCE AG (DE) 2010-04-15 WO disclosed