Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A5 | Q15758 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302384 | 1.00 | SLC1A5 (0.38) | SLC1A5KMOPGK1KCNN3HCAR1 | |
| SCHEMBL2303089 | 0.86 | CRHBP (0.31) | CRHBPCRHR2 | |
| SCHEMBL19012130 | 0.84 | SLC1A5 (0.36) | SLC1A5KMOPGK1HCAR1MPL | |
| SCHEMBL2301248 | 0.81 | CYP3A4 (0.34) | CRHBPCRHR2 | |
| SCHEMBL30826985 | 0.80 | SLC1A5 (0.36) | SLC1A5KMOPGK1HCAR1NOTUM | |
| SCHEMBL22028866 | 0.80 | SLC1A5 (0.36) | SLC1A5KMOPGK1HCAR1NOTUM | |
| SCHEMBL2306436 | 0.80 | SLC1A5 (0.36) | SLC1A5KMOPGK1KCNN3HCAR1 | |
| SCHEMBL19844892 | 0.76 | MBOAT4 (0.40) | SLC1A5KMOPGK1 | |
| SCHEMBL2301019 | 0.74 | KMO (0.45) | KMOEPHX2 | |
| SCHEMBL2306249 | 0.74 | KMO (0.49) | KMOEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746965-A1 | BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025017041-A1 | BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-23 | — | — | WO | disclosed |