Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29481460 | 1.00 | TACR1 (0.43) | TACR1RORCNR1H2NR1H3PDE4B | |
| SCHEMBL13093181 | 0.88 | NTRK1 (0.40) | RORCNR1H2NR1H3PDE4BNTRK1 | |
| SCHEMBL31703732 | 0.82 | RORC (0.51) | TACR1RORCNR1H2NR1H3 | |
| SCHEMBL25075376 | 0.82 | RORC (0.51) | TACR1RORCNR1H2NR1H3 | |
| SCHEMBL15054715 | 0.82 | RORC (0.51) | TACR1RORCNR1H2NR1H3 | |
| SCHEMBL556462 | 0.81 | PDE4B (0.43) | TACR1RORCNR1H2NR1H3PDE4B | |
| SCHEMBL25208441 | 0.81 | RORC (0.48) | TACR1RORCNR1H2NR1H3PDE4B | |
| SCHEMBL19270998 | 0.79 | PDE4B (0.50) | TACR1RORCPDE4BDPP4USP30 | |
| SCHEMBL5158474 | 0.79 | DPP4 (0.47) | TACR1RORCPDE4BDPP4USP30 | |
| SCHEMBL5159291 | 0.79 | DPP4 (0.47) | TACR1RORCPDE4BDPP4USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017586-A1 | ENZYME INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-29 | — | — | EP | disclosed |
| CN-114269431-A | Enzyme inhibitors | 卡尔维斯塔制药有限公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021032933-A1 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-25 | — | — | WO | disclosed |
| WO-2021032933-A1 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-25 | — | — | WO | disclosed |