SCHEMBL436025

SCHEMBL436025

COC(=O)N(C(CCCCNC(c1ccccc1)(c1ccccc1)c1ccc(C)cc1)C(=O)O)C1c2ccccc2-c2ccccc21

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ KIF11 P52732 5/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ DUT P33316 2/20 0.32
▸ FOLH1 Q04609 1/20 0.31
▸ MDM2 Q00987 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ TPSAB1 Q15661 2/20 0.30
▸ TPSD1 Q9BZJ3 2/20 0.30
▸ TPSG1 Q9NRR2 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL436023 1.00 KIF11 (0.34) KIF11MEN1LMNAKMT2ADUT
SCHEMBL19349124 0.88 DUT (0.39) KIF11MEN1KMT2ADUTTSHR
SCHEMBL19349125 0.88 DUT (0.39) KIF11MEN1KMT2ADUTTSHR
SCHEMBL8893033 0.83 CYP1A2 (0.37) KMT2AFOLH1TSHR
SCHEMBL8892535 0.83 CYP1A2 (0.37) KMT2AFOLH1TSHR
SCHEMBL25182246 0.80 PRSS1 (0.37) LMNAKMT2AALDH1A1
SCHEMBL4738904 0.80 EPOR (0.42) MDM2TSHR
SCHEMBL5548812 0.80 EPOR (0.42) MDM2TSHR
SCHEMBL25178739 0.79 FFAR1 (0.36) MEN1LMNAKMT2AALDH1A1
SCHEMBL25179548 0.79 CYP1A2 (0.34) KMT2AFOLH1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130143815-A1 GROWTH HORMONE CONJUGATES NOVO NORDISK HEALTH CARE AG (CH) 2013-06-06 — — US disclosed
EP-2595661-A1 GROWTH HORMONE CONJUGATES Novo Nordisk Health Care AG (CH) 2013-05-29 — — EP disclosed
WO-2012010516-A1 GROWTH HORMONE CONJUGATES NOVO NORDISK HEALTH CARE AG (CH) 2012-01-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130143815-A1 GROWTH HORMONE CONJUGATES GHRHR, GHSR, GHITM KIF11 545/4885MEN1 389/4885LMNA 4760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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