Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MRGPRX1 | Q96LB2 | 5/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23014676 | 0.84 | ACLY (0.65) | KDM4EALDH1A1HSD17B10HPGDMRGPRX1 | |
| SCHEMBL647703 | 0.79 | TSHR (0.82) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7065164 | 0.77 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL18594835 | 0.77 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL19335455 | 0.77 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL31393942 | 0.76 | ACLY (0.62) | KDM4EALDH1A1HSD17B10HPGDMRGPRX1 | |
| SCHEMBL1015878 | 0.75 | CA1 (0.58) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL27592220 | 0.75 | TSHR (0.47) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL21384614 | 0.75 | MRGPRX1 (0.57) | MRGPRX1ACLY | |
| SCHEMBL22638690 | 0.75 | MRGPRX1 (0.54) | KDM4EALDH1A1HSD17B10HPGDMRGPRX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12540115-B2 | Inhibitors of phospholipid synthesis and methods of use | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2026-02-03 | — | — | US | disclosed |
| US-20220315528-A1 | INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-10-06 | — | — | US | disclosed |
| WO-2021035031-A1 | INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2021-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220315528-A1 | INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE | LCAT, AGPAT2, AGPAT5 | KDM4E 3007/4885ALDH1A1 2938/4885HSD17B10 372/4885 |
| US-12540115-B2 | Inhibitors of phospholipid synthesis and methods of use | LCAT, DGAT1, DGAT2 | KDM4E 1824/4885ALDH1A1 1934/4885HSD17B10 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.