Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20297292 | 0.79 | DPP8 (0.36) | BACE1CTSDTRPV1HIF1ALMNA | |
| SCHEMBL19217077 | 0.77 | MAOA (0.41) | BRD4TSHRLMNAMAPTHTR2A | |
| SCHEMBL20897128 | 0.77 | RXRA (0.43) | ALDH1A1POLB | |
| SCHEMBL659413 | 0.76 | MAOB (0.39) | BACE1CTSDAHRHIF1AALDH1A1 | |
| SCHEMBL20906739 | 0.74 | ALDH1A1 (0.39) | ALDH1A1POLBTSHRLMNAMAPT | |
| SCHEMBL15075057 | 0.73 | MALT1 (0.46) | BACE1CTSDTRPV1AHRMAPT | |
| SCHEMBL18325499 | 0.73 | NR1H2 (0.49) | BACE1HIF1A | |
| SCHEMBL3877662 | 0.72 | BRD4 (0.41) | BRD4ALDH1A1POLBTSHR | |
| SCHEMBL22938912 | 0.71 | PGR (0.34) | BACE1CTSDTRPV1AHRPGR | |
| SCHEMBL9006983 | 0.70 | BACE1 (0.37) | BACE1CTSDBRD4AHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782996-A1 | NRF2 REGULATORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2021-02-24 | — | — | EP | disclosed |