Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | PTPRB | P23467 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18124167 | 1.00 | LMNA (0.59) | LMNAUSP30ROCK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18115963 | 0.86 | LMNA (0.69) | LMNAUSP30ROCK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18115961 | 0.86 | LMNA (0.69) | LMNAUSP30ROCK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27310734 | 0.86 | USP30 (0.65) | LMNAUSP30SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL27371502 | 0.81 | LMNA (0.58) | LMNAUSP30SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL25140726 | 0.79 | ENPP2 (0.53) | USP30ENPP2 | |
| SCHEMBL9892928 | 0.78 | SMN1; SMN2 (0.56) | LMNAUSP30SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL6182814 | 0.76 | ITGB3 (0.54) | USP30ALDH1A1RAB9AENPP2MAPT | |
| SCHEMBL13719821 | 0.76 | USP30 (0.55) | USP30PTPRB | |
| SCHEMBL7533964 | 0.76 | ENPP2 (0.51) | USP30ALDH1A1RAB9AENPP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112707893-B | 1-cyanopyrrolidine compounds as USP30 inhibitors | 特殊治疗有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-112707893-A | 1-cyanopyrrolidine compounds as USP30 inhibitors | 特殊治疗有限公司 | 2021-04-27 | — | — | CN | disclosed |
| EP-3277677-B1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2021-02-24 | — | — | EP | disclosed |
| CN-107484415-B | 1-cyanopyrrolidine compounds as USP30 inhibitors | 特殊治疗有限公司 | 2021-01-29 | — | — | CN | disclosed |