Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423289 | 0.85 | TSHR (0.50) | ALDH1A1TSHRG6PC1AOC3NPC1 | |
| SCHEMBL2659990 | 0.81 | TSHR (0.48) | ALDH1A1TSHRG6PC1AOC3NPC1 | |
| Alcohol SCHEMBL7695411 | 0.79 | G6PC1 (0.46) | ALDH1A1TSHRG6PC1AOC3NPC1 | |
| SCHEMBL27446334 | 0.78 | ALDH1A1 (0.43) | ALDH1A1TSHRG6PC1AOC3NPC1 | |
| SCHEMBL20670478 | 0.76 | ALDH1A1 (0.43) | ALDH1A1TSHRAOC3NPC1RAB9A | |
| SCHEMBL17632159 | 0.75 | TSHR (0.41) | ALDH1A1TSHRG6PC1AOC3NPC1 | |
| SCHEMBL23867189 | 0.74 | SMN1; SMN2 (0.41) | ALDH1A1TSHRG6PC1AOC3NPC1 | |
| SCHEMBL9079988 | 0.74 | LTA4H (0.52) | NR3C1 | |
| SCHEMBL27491750 | 0.72 | TSHR (0.52) | ALDH1A1TSHRAOC3NPC1RAB9A | |
| SCHEMBL2659567 | 0.71 | TSHR (0.54) | ALDH1A1TSHRAOC3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277677-B9 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2021-07-14 | — | — | EP | disclosed |
| EP-3277677-B1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2021-02-24 | — | — | EP | disclosed |