Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2399645 | 0.81 | MTNR1A (0.49) | CYP3A4MTNR1AMTNR1B | |
| SCHEMBL2305820 | 0.80 | HSD17B10 (0.57) | CYP3A4MTNR1AMTNR1BTSHR | |
| SCHEMBL2826592 | 0.76 | HSD17B10 (0.67) | MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL4405092 | 0.76 | HSD17B10 (0.46) | CTSDMEN1TSHRKMT2A | |
| SCHEMBL6868625 | 0.76 | MEN1 (0.63) | MEN1TSHRKMT2A | |
| SCHEMBL17730692 | 0.75 | HTT (0.50) | SMN1; SMN2KMT2A | |
| SCHEMBL23619807 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2 | |
| SCHEMBL31116543 | 0.74 | DPP4 (0.48) | CYP3A4MTNR1AMTNR1BSMN1; SMN2MEN1 | |
| SCHEMBL29907950 | 0.73 | GAA (0.64) | SMN1; SMN2CTSDMEN1TSHRKMT2A | |
| SCHEMBL2826584 | 0.73 | GAA (0.64) | SMN1; SMN2CTSDMEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349983-B1 | DIFLUORPHENYL DIACYLHYDRAZIDE DERIVATES | MERCK PATENT GMBH (DE) | 2016-09-14 | — | — | EP | disclosed |
| EP-2349983-B1 | DIFLUORPHENYL DIACYLHYDRAZIDE DERIVATES | MERCK PATENT GMBH (DE) | 2016-09-14 | — | — | EP | disclosed |
| US-8492440-B2 | Difluorophenyldiacylhydrazide derivatives | MERCK PATENT GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-8492440-B2 | Difluorophenyldiacylhydrazide derivatives | MERCK PATENT GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-8492440-B2 | Difluorophenyldiacylhydrazide derivatives | MERCK PATENT GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20110224302-A1 | DIFLUOROPHENYLDIACYLHYDRAZIDE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-09-15 | — | — | US | disclosed |
| US-20110224302-A1 | DIFLUOROPHENYLDIACYLHYDRAZIDE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-09-15 | — | — | US | disclosed |
| US-20110224302-A1 | DIFLUOROPHENYLDIACYLHYDRAZIDE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-09-15 | — | — | US | disclosed |
| EP-2349983-A2 | DIFLUORPHENYL DIACYLHYDRAZIDE DERIVATES | Merck Patent GmbH (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010060522-A2 | DIFLUORPHENYL DIACYLHYDRAZIDE DERIVATES | MERCK PATENT GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |
| WO-2010060522-A2 | DIFLUORPHENYL DIACYLHYDRAZIDE DERIVATES | MERCK PATENT GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224302-A1 | DIFLUOROPHENYLDIACYLHYDRAZIDE DERIVATIVES | FGFR1, PKD1, AGTR1 | CYP3A4 2246/4885MTNR1A 1836/4885MTNR1B 1144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.