Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23930713 | 0.75 | SIGMAR1 (0.32) | SIGMAR1 | |
| SCHEMBL24742538 | 0.75 | AAK1 (0.32) | SIGMAR1 | |
| SCHEMBL23022287 | 0.69 | SIGMAR1 (0.48) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL4463156 | 0.69 | CHRNB2 (0.33) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL31618365 | 0.68 | CHRNB2 (0.38) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL31618283 | 0.68 | CHRNB2 (0.35) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL147460 | 0.68 | — | — | |
| SCHEMBL6871401 | 0.66 | CHRNB2 (0.36) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL15156228 | 0.62 | SIGMAR1 (0.54) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL31059064 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032148-A1 | AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-02-25 | — | — | WO | disclosed |