Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330161 | 0.81 | DPP7 (0.47) | DPP7MEN1KMT2ATDP1 | |
| SCHEMBL22262519 | 0.79 | MTNR1A (0.56) | CHRM2CHRM4CHRM1CHRM3MTNR1A | |
| SCHEMBL29659985 | 0.79 | MTNR1A (0.56) | CHRM2CHRM4CHRM1CHRM3MTNR1A | |
| SCHEMBL22262517 | 0.79 | MTNR1A (0.56) | CHRM2CHRM4CHRM1CHRM3MTNR1A | |
| SCHEMBL18778628 | 0.76 | CHRM2 (0.53) | CHRM2CHRM4CHRM1CHRM3MTNR1A | |
| SCHEMBL4231534 | 0.76 | SLC6A2 (0.54) | CHRM2CHRM4CHRM1CHRM3MTNR1A | |
| SCHEMBL21410447 | 0.75 | CHRM2 (0.53) | CHRM2CHRM4CHRM1CHRM3MTNR1A | |
| SCHEMBL10767939 | 0.74 | CHRM2 (0.61) | CHRM2CHRM4CHRM1CHRM3MTNR1A | |
| SCHEMBL10689309 | 0.72 | HRH3 (0.58) | CHRM2CHRM4CHRM1CHRM3MTNR1A | |
| SCHEMBL23023057 | 0.71 | ALDH1A1 (0.56) | CHRM2CHRM4CHRM1CHRM3DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210053997-A1 | TRNA SYNTHETASE INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210053997-A1 | TRNA SYNTHETASE INHIBITORS | TRMT1, AARS1, GARS1 | CHRM2 4851/4885CHRM4 4865/4885CHRM1 4821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.