Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 13/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 13/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20229787 | 0.82 | OPRM1 (0.67) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL21179656 | 0.82 | OPRM1 (0.67) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5364158 | 0.74 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1HTR4 | |
| SCHEMBL23034756 | 0.74 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1HTR4 | |
| SCHEMBL23034747 | 0.74 | OPRM1 (0.67) | OPRM1OPRD1OPRK1OPRL1HTR4 | |
| SCHEMBL23034936 | 0.72 | OPRM1 (0.53) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL31187546 | 0.71 | OPRL1 (0.36) | OPRM1OPRD1OPRK1OPRL1HTR4 | |
| SCHEMBL20213272 | 0.71 | OPRL1 (0.36) | OPRM1OPRD1OPRK1OPRL1HTR4 | |
| SCHEMBL15642774 | 0.71 | NOD2 (0.50) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL23034745 | 0.71 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827617-B2 | Piperidinyl nociceptin receptor compounds | ASTRAEA THERAPEUTICS, LLC (US) | 2023-11-28 | — | — | US | disclosed |
| US-20210053937-A1 | PIPERIDINYL NOCICEPTIN RECEPTOR COMPOUNDS | ASTRAEA THERAPEUTICS, LLC | 2021-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827617-B2 | Piperidinyl nociceptin receptor compounds | OPRL1, OPRK1, OPRM1 | OPRM1 3/4885OPRD1 5/4885OPRK1 2/4885 |
| US-20210053937-A1 | PIPERIDINYL NOCICEPTIN RECEPTOR COMPOUNDS | OPRL1, OPRK1, OPRM1 | OPRM1 3/4885OPRD1 5/4885OPRK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.