Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337816 | 0.69 | LTA4H (0.46) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL7348148 | 0.68 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL7340701 | 0.68 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL7340708 | 0.68 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL2110717 | 0.66 | CHRNB2 (0.50) | CHRNB2CHRNA4LTA4HALDH1A1MEN1 | |
| SCHEMBL4292893 | 0.65 | CHRNB2 (0.49) | CHRNB2CHRNA4LTA4HHRH3MEN1 | |
| Hydrochloric Acid SCHEMBL2333516 | 0.65 | CHRNB2 (0.49) | CHRNB2CHRNA4LTA4HALDH1A1MEN1 | |
| SCHEMBL3441563 | 0.64 | CHRNB2 (0.48) | CHRNB2CHRNA4LTA4HSLC6A4 | |
| SCHEMBL3441821 | 0.64 | CHRNB2 (0.48) | CHRNB2CHRNA4LTA4HMEN1CYP2D6 | |
| SCHEMBL2146296 | 0.64 | NPC1 (0.52) | CHRM2CHRM1CHRM3LTA4HSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350003-A1 | SUBSTITUTED DISULFONAMIDES AS BRI-MODULATORS | Grünenthal GmbH (DE) | 2011-08-03 | — | — | EP | disclosed |
| US-20100152158-A1 | Substituted Disulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-06-17 | — | — | US | disclosed |
| WO-2010051977-A1 | SUBSTITUTED DISULFONAMIDES AS BRI-MODULATORS | Grünenthal GmbH (DE) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152158-A1 | Substituted Disulfonamide Compounds | BDKRB1, BDKRB2, BRS3 | CHRNB2 700/4885CHRNA4 912/4885CHRM2 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.