Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.56 |
| ▸ | AURKA | O14965 | 7/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 7/20 | 0.49 |
| ▸ | BLK | P51451 | 6/20 | 0.49 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | PLK4 | O00444 | 5/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.49 |
| ▸ | LCK | P06239 | 5/20 | 0.49 |
| ▸ | CLK2 | P49760 | 5/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.49 |
| ▸ | NEK2 | P51955 | 5/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.49 |
| ▸ | CSNK1G2 | P78368 | 5/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.49 |
| ▸ | STK3 | Q13188 | 5/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 5/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684025 | 0.93 | FLT3 (0.55) | FLT3AURKAAURKBIKBKEAXL | |
| SCHEMBL23043916 | 0.93 | FLT3 (0.55) | FLT3AURKAAURKBIKBKEAXL | |
| SCHEMBL23043903 | 0.89 | FLT3 (0.50) | FLT3AURKAAURKBIKBKEAXL | |
| SCHEMBL29747011 | 0.87 | EIF2AK3 (0.52) | FLT3AURKAAURKBAXLKDR | |
| SCHEMBL23043972 | 0.87 | EIF2AK3 (0.52) | FLT3AURKAAURKBAXLKDR | |
| SCHEMBL23043850 | 0.84 | MET (0.49) | FLT3AXLRETCDK1MET | |
| SCHEMBL29746670 | 0.84 | MET (0.49) | FLT3AXLRETCDK1MET | |
| SCHEMBL23057572 | 0.81 | FLT3 (0.44) | FLT3AXLRETCDK1MET | |
| SCHEMBL23043945 | 0.81 | MET (0.47) | FLT3AXLMAP4K4METEIF2AK3 | |
| SCHEMBL23044049 | 0.81 | EIF2AK3 (0.51) | FLT3AXLKDRCSF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356186-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. | 2022-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356186-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | EEF2K, ATF4, MAPKAPK2 | FLT3 1250/4885AURKA 3121/4885AURKB 1999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.