Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 10/20 | 0.44 |
| ▸ | CA1 | P00915 | 8/20 | 0.44 |
| ▸ | CA9 | Q16790 | 7/20 | 0.44 |
| ▸ | CA12 | O43570 | 5/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | PRF1 | P14222 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846072 | 0.85 | PTGES2 (0.54) | KIF11PTGES2CA2CA1CA9 | |
| SCHEMBL2311184 | 0.81 | LRRK2 (0.56) | CA2CA1CA9CA12LRRK2 | |
| SCHEMBL6732634 | 0.80 | PTGS1 (0.61) | KIF11CA2CA1CA9CA12 | |
| SCHEMBL2311228 | 0.77 | ABL1 (0.53) | PTGES2CA2CA1CA9CA12 | |
| SCHEMBL6724538 | 0.77 | PTGS1 (0.58) | KIF11PTGES2CA2CA1CA9 | |
| SCHEMBL6733336 | 0.75 | PTGS2 (0.67) | KIF11CA2CA1CA9CA12 | |
| SCHEMBL6725503 | 0.75 | PTGS2 (0.61) | KIF11CA2CA9CA12 | |
| SCHEMBL28312069 | 0.75 | IKBKB (0.54) | KIF11CA2CA1CA9CA12 | |
| SCHEMBL1069772 | 0.74 | CA2 (0.51) | KIF11CA2CA1CA9CA12 | |
| SCHEMBL4733933 | 0.73 | CA2 (0.61) | CA2CA1CA9CA12LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349990-A1 | ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE | Pimco 2664 Limited (GB) | 2011-08-03 | — | — | EP | disclosed |