Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28043538 | 0.80 | ALDH1A1 (0.40) | LMNAALDH1A1TSHRTDP1HSD17B10 | |
| SCHEMBL1851945 | 0.79 | LMNA (0.34) | LMNAKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL7314143 | 0.77 | KDM4E (0.35) | LMNAKDM4EHSD17B10 | |
| SCHEMBL23049725 | 0.77 | LMNA (0.33) | LMNAKDM4EHSD17B10 | |
| SCHEMBL25383365 | 0.77 | ALDH1A1 (0.39) | LMNAALDH1A1TSHRTDP1HSD17B10 | |
| SCHEMBL30082486 | 0.75 | KDM4E (0.31) | LMNAKDM4E | |
| SCHEMBL19906343 | 0.75 | TET2 (0.32) | ALDH1A1TSHRTDP1GAA | |
| SCHEMBL25383367 | 0.75 | ALDH1A1 (0.38) | LMNAALDH1A1TSHRTDP1HSD17B10 | |
| SCHEMBL9325262 | 0.74 | SERPINE1 (0.32) | LMNAKDM4EHSD17B10 | |
| SCHEMBL3177457 | 0.74 | CYP1A2 (0.47) | LMNAALDH1A1KDM4EHSD17B10MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596064-B1 | TOSYLACETATE BASED COMPOUNDS AND DERIVATIVES THEREOF AS PHGDH INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2021-03-03 | — | — | EP | disclosed |