Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585074 | 0.84 | — | — | |
| SCHEMBL23615766 | 0.83 | PRKCA (0.34) | TSHRLMNAMAPTTDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4596140 | 0.82 | TSHR (0.45) | TSHRKDM4ELMNAMAPTGAA | |
| SCHEMBL15131420 | 0.81 | MGAM (0.50) | TSHRMAPTMGAMGAASI | |
| SCHEMBL445120 | 0.80 | NAAA (0.39) | TSHRLMNAMAPTTDP1ALDH1A1 | |
| SCHEMBL27835213 | 0.80 | MAPT (0.37) | TSHRKDM4ELMNAMAPTTDP1 | |
| SCHEMBL1852850 | 0.80 | KDM4E (0.34) | KDM4ELMNAMGAMGAASI | |
| SCHEMBL15283587 | 0.79 | MAPT (0.38) | TSHRKDM4ELMNAMAPTTDP1 | |
| SCHEMBL4981295 | 0.78 | TSHR (0.46) | TSHRMAPTTDP1L3MBTL1PRKCA | |
| SCHEMBL9935949 | 0.78 | TSHR (0.38) | TSHRMAPTTDP1L3MBTL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596064-B1 | TOSYLACETATE BASED COMPOUNDS AND DERIVATIVES THEREOF AS PHGDH INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2021-03-03 | — | — | EP | disclosed |