Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302646 | 0.88 | BCL2 (0.56) | BCL2PTGS2GRIA2SHMT1SHMT2 | |
| SCHEMBL21997278 | 0.88 | GRIA2 (0.50) | BCL2PTGS2GRIA2SHMT1SHMT2 | |
| SCHEMBL13061620 | 0.87 | BCL2 (0.64) | BCL2PTGS2MMERXRARXRB | |
| SCHEMBL15214656 | 0.86 | BCL2 (0.53) | BCL2PTGS2GRIA2SHMT1SHMT2 | |
| SCHEMBL8413101 | 0.85 | MMP3 (0.54) | BCL2PTGS2GRIA2SHMT1SHMT2 | |
| SCHEMBL2303566 | 0.83 | BCL2 (0.47) | BCL2PTGS2GRIA2SHMT1SHMT2 | |
| SCHEMBL2303529 | 0.83 | SHMT1 (0.60) | BCL2PTGS2GRIA2SHMT1SHMT2 | |
| SCHEMBL2304146 | 0.83 | AGXT (0.57) | BCL2PTGS2GRIA2SHMT1SHMT2 | |
| SCHEMBL8416493 | 0.83 | BCL2 (0.47) | BCL2PTGS2GRIA2SHMT1SHMT2 | |
| SCHEMBL13905068 | 0.82 | BCL2 (0.47) | BCL2PTGS2RXRARXRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |