Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.75 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.51 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29382834 | 0.90 | CYP1A2 (0.77) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 | |
| SCHEMBL996941 | 0.90 | CYP1A2 (0.77) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 | |
| SCHEMBL24486720 | 0.89 | CYP1A2 (0.75) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 | |
| SCHEMBL12787804 | 0.87 | CYP1A2 (0.72) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 | |
| SCHEMBL14595147 | 0.87 | CYP1A2 (0.72) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 | |
| Lonidamine SCHEMBL7134 | 0.86 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 | |
| SCHEMBL31566279 | 0.86 | CYP1A2 (0.82) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 | |
| Lonidamine SCHEMBL29351122 | 0.86 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 | |
| SCHEMBL21121979 | 0.86 | CYP1A2 (0.82) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 | |
| Lonidamine SCHEMBL29350056 | 0.86 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352382-B2 | Mito-lonidamine, compositions and methods of use | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20210061830-A1 | MITO-LONIDAMINE, COMPOSITIONS AND METHODS OF USE | AIX-MARSEILLE UNIVERSITE (FR) | 2021-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061830-A1 | MITO-LONIDAMINE, COMPOSITIONS AND METHODS OF USE | COX5B, COX5A, LONP1 | CYP1A2 613/4885CYP3A4 807/4885CYP2C9 398/4885 |
| US-11352382-B2 | Mito-lonidamine, compositions and methods of use | COX5B, COX5A, LONP1 | CYP1A2 613/4885CYP3A4 807/4885CYP2C9 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.