Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.41 |
| ▸ | EIF2AK3 | Q9NZJ5 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30062898 | 1.00 | CRHR1 (0.41) | CRHR1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL29684355 | 0.84 | CRHR1 (0.39) | CRHR1EIF2AK3HAVCR2ADORA1ALDH1A1 | |
| SCHEMBL23043996 | 0.84 | CRHR1 (0.39) | CRHR1EIF2AK3HAVCR2ADORA1ALDH1A1 | |
| SCHEMBL23057766 | 0.79 | CRHR1 (0.36) | CRHR1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL20351734 | 0.76 | SRC (0.49) | EIF2AK3CYP3A4EIF2AK2EIF2AK1TGFBR1 | |
| SCHEMBL23057767 | 0.72 | DYRK1A (0.39) | EIF2AK3CYP3A4EIF2AK2EIF2AK1SRC | |
| SCHEMBL30060898 | 0.72 | HAVCR2 (0.37) | EIF2AK3CYP3A4HAVCR2ADORA1ALDH1A1 | |
| SCHEMBL30060936 | 0.72 | DYRK1A (0.39) | EIF2AK3CYP3A4EIF2AK2EIF2AK1SRC | |
| SCHEMBL23057764 | 0.72 | HAVCR2 (0.37) | EIF2AK3CYP3A4HAVCR2ADORA1ALDH1A1 | |
| SCHEMBL23057749 | 0.72 | EIF2AK3 (0.47) | EIF2AK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041975-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |