Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23058148 | 0.85 | MAPT (0.35) | THRATHRBMAPT | |
| SCHEMBL23058181 | 0.78 | PDE2A (0.39) | SLC6A3 | |
| SCHEMBL23058476 | 0.78 | NPSR1 (0.36) | MAPTCNR2 | |
| SCHEMBL23058643 | 0.78 | CHRM2 (0.36) | THRATHRBALOX5ESR1ESR2 | |
| SCHEMBL23058713 | 0.77 | GAA (0.32) | — | |
| SCHEMBL23058746 | 0.76 | L3MBTL1 (0.44) | MAPTSLC6A2SLC6A3 | |
| SCHEMBL23058793 | 0.72 | LMNA (0.38) | — | |
| SCHEMBL12111408 | 0.72 | ESR1 (0.41) | PRKCAPRKCDESR1ESR2SLC6A2 | |
| SCHEMBL23718452 | 0.71 | AOC3 (0.36) | MAPTSLC6A2SLC6A3 | |
| SCHEMBL7770556 | 0.70 | DNM1 (0.32) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041588-A1 | SUBSTITUTED PYRIDOPYRIMIDINONYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-03-04 | — | — | WO | disclosed |