Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 11/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 4/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | F13A1 | P00488 | 1/20 | 0.31 |
| ▸ | TGM1 | P22735 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.30 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23060277 | 0.80 | MAPK3 (0.37) | FGFR1FGFR4EGFRITKMAPK3 | |
| SCHEMBL23060231 | 0.79 | CFTR (0.34) | — | |
| SCHEMBL24594005 | 0.76 | FGFR4 (0.45) | FGFR1FGFR4EGFRITKMET | |
| SCHEMBL23060180 | 0.76 | GSTO1 (0.41) | EGFRTGM2JAK3 | |
| SCHEMBL28553497 | 0.75 | KDM4E (0.42) | FGFR1FGFR4EGFRTGM2BTK | |
| SCHEMBL23060172 | 0.75 | TGM2 (0.34) | FGFR4EGFRITKTGM2BTK | |
| SCHEMBL23044895 | 0.73 | FGFR1 (0.39) | FGFR1FGFR4EGFRKDR | |
| SCHEMBL23060271 | 0.69 | KDM4E (0.38) | FGFR1FGFR4EGFRTGM2MAPK3 | |
| SCHEMBL21430724 | 0.67 | FGFR4 (0.43) | FGFR1FGFR4TGM2KDR | |
| SCHEMBL23060053 | 0.66 | GSTO1 (0.41) | EGFRTGM2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021037219-A1 | PYRAZOLE DERIVATIVE FOR FGFR INHIBITOR AND PREPARATION METHOD THEREFOR | 上海奕拓医药科技有限责任公司 | 2021-03-04 | — | — | WO | disclosed |