Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 4/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28553497 | 0.84 | KDM4E (0.42) | KDM4EATMBTKTGM2FGFR1 | |
| SCHEMBL23060053 | 0.82 | GSTO1 (0.41) | KDM4ETGM2EGFRALDH1A1HPGD | |
| SCHEMBL23060180 | 0.78 | GSTO1 (0.41) | KDM4ETGM2EGFRALDH1A1HPGD | |
| SCHEMBL23060172 | 0.77 | TGM2 (0.34) | BTKTGM2FGFR4EGFRALDH1A1 | |
| SCHEMBL23060193 | 0.77 | FGFR4 (0.49) | FGFR1FGFR4EGFRMAPK3 | |
| SCHEMBL29214301 | 0.76 | KDM4E (0.41) | KDM4EATMBTKTGM2FGFR1 | |
| SCHEMBL28549394 | 0.74 | CFTR (0.56) | KDM4EATMBTKTGM2FGFR4 | |
| SCHEMBL21431003 | 0.73 | GSTO1 (0.46) | KDM4ETGM2EGFRALDH1A1HPGD | |
| SCHEMBL23044925 | 0.73 | ALDH1A1 (0.46) | KDM4EATMBTKTGM2FGFR4 | |
| SCHEMBL21392831 | 0.70 | KDM4E (0.70) | KDM4EATMALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023639-A1 | PYRAZOLE DERIVATIVE FOR FGFR INHIBITOR AND PREPARATION METHOD THEREFOR | Etern Biopharma (Shanghai) Co., Ltd. (CN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2021037219-A1 | PYRAZOLE DERIVATIVE FOR FGFR INHIBITOR AND PREPARATION METHOD THEREFOR | 上海奕拓医药科技有限责任公司 | 2021-03-04 | — | — | WO | disclosed |