Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13868420 | 0.84 | CYP3A4 (0.56) | CYP3A4CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL22039743 | 0.81 | CYP3A4 (0.61) | CYP3A4CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL24419593 | 0.81 | ESR1 (0.50) | CYP3A4CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL13965851 | 0.80 | CHRM2 (0.58) | CYP3A4CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL1796909 | 0.79 | LMNA (0.77) | CYP3A4CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL184001 | 0.79 | LMNA (0.77) | CYP3A4CYP2D6CYP2C9CYP2C19LMNA | |
| Hydrochloric Acid SCHEMBL5378426 | 0.79 | CYP3A4 (0.59) | CYP3A4CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL21799683 | 0.79 | TPSAB1 (0.42) | CYP3A4CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL5461543 | 0.78 | MEN1 (0.56) | CYP3A4KMT2ACHRM2MEN1 | |
| SCHEMBL4029852 | 0.78 | LMNA (0.62) | CYP3A4CYP2D6CYP2C9CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070743-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070743-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIPK1, RIPK2, RIPK3 | CYP3A4 4866/4885CYP2D6 4874/4885CYP2C9 4879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.