Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.64 |
| ▸ | MAOA | P21397 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | MAOB | P27338 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Genistein SCHEMBL1373525 | 0.82 | SMN1; SMN2 (0.60) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 | |
| Daidzein SCHEMBL2025991 | 0.81 | KDM4E (0.86) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 | |
| SCHEMBL232753 | 0.80 | KDM4E (0.74) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 | |
| Daidzein SCHEMBL19814 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 | |
| Daidzein SCHEMBL21114371 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 | |
| Daidzein SCHEMBL29374778 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 | |
| SCHEMBL1607109 | 0.80 | MAOA (0.56) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 | |
| Daidzein SCHEMBL28743634 | 0.78 | KDM4E (0.76) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 | |
| Daidzein SCHEMBL4188877 | 0.77 | SMN1; SMN2 (0.70) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 | |
| 7-Hydroxy Isoflavone SCHEMBL762528 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10MAOASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349254-B1 | SKIN EXTERNAL COMPOSITION FOR INHIBITING EPIDERMAL HYPERPROLIFERATION AND ALLEVIATING INFLAMMATORY SKIN DISEASES CONTAINING ORTHO-DIHYDROXYISOFLAVONE DERIVATIVES | AMOREPACIFIC CORP (KR) | 2018-07-25 | — | — | EP | disclosed |
| US-20110224291-A1 | SKIN EXTERNAL COMPOSITION FOR INHIBITING EPIDERMAL HYPERPROLIFERATION AND ALLEVIATING INFLAMMATORY SKIN DISEASES CONTAINING ORTHODIHYDROXYISOFLAVONE DERIVATIVES | AMOREPACIFIC CORPORATION (KR) | 2011-09-15 | — | — | US | disclosed |
| EP-2349254-A2 | SKIN EXTERNAL COMPOSITION FOR INHIBITING EPIDERMAL HYPERPROLIFERATION AND ALLEVIATING INFLAMMATORY SKIN DISEASES CONTAINING ORTHO-DIHYDROXYISOFLAVONE DERIVATIVES | Amorepacific Corporation (KR) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010058936-A2 | SKIN EXTERNAL COMPOSITION FOR INHIBITING EPIDERMAL HYPERPROLIFERATION AND ALLEVIATING INFLAMMATORY SKIN DISEASES CONTAINING ORTHO-DIHYDROXYISOFLAVONE DERIVATIVES | AMOREPACIFIC CORPORATION (KR) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224291-A1 | SKIN EXTERNAL COMPOSITION FOR INHIBITING EPIDERMAL HYPERPROLIFERATION AND ALLEVIATING INFLAMMATORY SKIN DISEASES CONTAINING ORTHODIHYDROXYISOFLAVONE DERIVATIVES | DKK1, FZD7, CTNND1 | KDM4E 2677/4885ALDH1A1 4396/4885HSD17B10 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.