SCHEMBL23093069

SCHEMBL23093069

CCCCc1cc(C)c(N)cc1C

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.59
SKP2 Q13309 1/20 0.53
CYP1A2 P05177 1/20 0.48
ALOX15 P16050 1/20 0.48
CASP7 P55210 1/20 0.48
HIF1A Q16665 1/20 0.48
HSD17B10 Q99714 1/20 0.48
MAPK1 P28482 2/20 0.46
CYP3A4 P08684 1/20 0.46
TSHR P16473 1/20 0.46
NOS2 P35228 2/20 0.39
TLR8 Q9NR97 2/20 0.39
TYR P14679 1/20 0.37
GABRP O00591 1/20 0.37
GABRD O14764 1/20 0.37
GABRA1 P14867 1/20 0.37
GABRB1 P18505 1/20 0.37
GABRG2 P18507 1/20 0.37
GABRB3 P28472 1/20 0.37
GABRA5 P31644 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14962818 0.87 ALDH1A1 (0.64) ALDH1A1SKP2CYP1A2ALOX15CASP7
SCHEMBL18536009 0.85 SKP2 (0.50) ALDH1A1SKP2CYP1A2ALOX15CASP7
SCHEMBL5372842 0.84 ALDH1A1 (0.73) ALDH1A1SKP2CYP1A2ALOX15CASP7
SCHEMBL20012353 0.84 SKP2 (0.46) ALDH1A1SKP2CYP1A2ALOX15CASP7
SCHEMBL11276129 0.83 SKP2 (0.44) ALDH1A1SKP2ALOX15MAPK1CYP3A4
SCHEMBL10615570 0.80 ALDH1A1 (0.55) ALDH1A1SKP2CYP1A2ALOX15CASP7
SCHEMBL16424254 0.79 SKP2 (0.40) ALDH1A1SKP2ALOX15MAPK1CYP3A4
SCHEMBL20816041 0.78 ALOX5 (0.48) ALDH1A1ALOX15HIF1AHSD17B10CYP3A4
SCHEMBL28656722 0.78 ALDH1A1 (0.70) ALDH1A1SKP2CYP1A2ALOX15CASP7
SCHEMBL4666138 0.76 SKP2 (0.46) ALDH1A1SKP2CYP1A2ALOX15CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021050547-A1 MITOCHONDRIAL COMPLEX I INHIBITORS AND METHODS OF USE Sanford Burnham Prebys Medical Discovery Institute (US) 2021-03-18 WO claimed
WO-2021050547-A1 MITOCHONDRIAL COMPLEX I INHIBITORS AND METHODS OF USE Sanford Burnham Prebys Medical Discovery Institute (US) 2021-03-18 WO disclosed
WO-2021050547-A1 MITOCHONDRIAL COMPLEX I INHIBITORS AND METHODS OF USE Sanford Burnham Prebys Medical Discovery Institute (US) 2021-03-18 WO disclosed