Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SKP2 | Q13309 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL833088 | 0.86 | SKP2 (0.47) | SKP2ALDH1A1CYP1A2ALOX15CASP7 | |
| SCHEMBL23093069 | 0.85 | ALDH1A1 (0.59) | SKP2ALDH1A1CYP1A2ALOX15CASP7 | |
| SCHEMBL10615570 | 0.82 | ALDH1A1 (0.55) | SKP2ALDH1A1CYP1A2ALOX15CASP7 | |
| SCHEMBL5379612 | 0.80 | SKP2 (0.42) | SKP2ALDH1A1CYP1A2ALOX15CASP7 | |
| SCHEMBL11114074 | 0.79 | TLR8 (0.46) | SKP2ALOX15CYP3A4TSHRTLR8 | |
| SCHEMBL841582 | 0.77 | ALOX5 (0.47) | ALOX15CYP3A4TSHRTLR8TYR | |
| SCHEMBL15486053 | 0.77 | ALOX5 (0.47) | ALOX15CYP3A4TSHRTLR8TYR | |
| SCHEMBL31265135 | 0.77 | TYR (0.41) | SKP2ALDH1A1ALOX15MAPK1CYP3A4 | |
| SCHEMBL27671383 | 0.77 | SKP2 (0.44) | SKP2ALDH1A1CYP1A2ALOX15CASP7 | |
| SCHEMBL11276129 | 0.77 | SKP2 (0.44) | SKP2ALDH1A1ALOX15MAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290419-A1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-07 | — | — | EP | disclosed |
| EP-2880026-B1 | DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-02-22 | — | — | EP | disclosed |