Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 9/20 | 0.46 |
| ▸ | CTSG | P08311 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL1295529 | 0.98 | CMA1 (0.45) | CMA1CTSGHTR2AHTR2CHTR2B | |
| SCHEMBL2931184 | 0.82 | HTR2C (0.63) | HTR2AHTR2CHTR2BGPR84CHRNB2 | |
| SCHEMBL10259878 | 0.82 | HTR2A (0.41) | HTR2AHTR2CHTR2BGPR84CDK2 | |
| SCHEMBL4552632 | 0.81 | CMA1 (0.52) | CMA1CTSGHTR2AHTR2CHTR2B | |
| Iodide SCHEMBL5399054 | 0.81 | CHRNB2 (0.41) | HTR2AHTR2CHTR2BGPR84CDK2 | |
| SCHEMBL1093151 | 0.80 | CMA1 (0.46) | CMA1CTSGHTR2AHTR2CHTR2B | |
| SCHEMBL7963410 | 0.79 | CMA1 (0.48) | CMA1CTSGHTR2AHTR2CHTR2B | |
| Iodide SCHEMBL5265553 | 0.79 | CMA1 (0.45) | CMA1CTSGHTR2AHTR2CHTR2B | |
| Ammonia Solution, Strong SCHEMBL27500614 | 0.78 | CMA1 (0.47) | CMA1CTSGHTR2AHTR2CHTR2B | |
| SCHEMBL4572379 | 0.78 | HTR2A (0.48) | CMA1CTSGHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150556-B2 | Benzimidazolone chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| US-9150556-B2 | Benzimidazolone chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| US-9062056-B2 | Aza-benzimidazolone Chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-06-23 | — | — | US | disclosed |
| US-8501749-B2 | Azaquinazolinediones chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-06 | — | — | US | disclosed |
| EP-2391624-B1 | AZAQUINAZOLINEDIONES USEFUL AS CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2013-01-16 | — | — | EP | disclosed |
| US-20120108597-A1 | Azaquinazolinediones Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20110269780-A1 | AZA-BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| EP-2152674-B1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2011-08-03 | — | — | EP | disclosed |
| US-20100240702-A1 | Benzimidazolone Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
| US-20100240702-A1 | Benzimidazolone Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
| WO-2010088195-A1 | AZAQUINAZOLINEDIONES USEFUL AS CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010030500-A1 | AZA-BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-18 | — | — | WO | disclosed |
| WO-2008147697-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-04 | — | — | WO | disclosed |
| CN-100415723-C | Benzimidazole derivative | TEIJIN LTD (JP) | 2008-09-03 | — | — | CN | disclosed |
| CN-1680339-A | Benzimidazole derivative | TEIJIN LTD (JP) | 2005-10-12 | — | — | CN | disclosed |
| CN-1198819-C | Benzimidazole derivatives | TEIJIN LTD (JP) | 2005-04-27 | — | — | CN | disclosed |
| CN-1418211-A | Benzimidazole derivatives | TEIJIN LTD (JP) | 2003-05-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108597-A1 | Azaquinazolinediones Chymase Inhibitors | CMA1, SERPINB1, CTSC | CMA1 1/4885CTSG 37/4885HTR2A 3852/4885 |
| US-20110269780-A1 | AZA-BENZIMIDAZOLONE CHYMASE INHIBITORS | CMA1, CPA3, SERPINB1 | CMA1 1/4885CTSG 26/4885HTR2A 3704/4885 |
| US-20100240702-A1 | Benzimidazolone Chymase Inhibitors | CMA1, SERPINB1, CPA3 | CMA1 1/4885CTSG 26/4885HTR2A 3241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.