Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 10/20 | 0.45 |
| ▸ | MMP13 | P45452 | 4/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152274 | 0.90 | ADAMTS4 (0.47) | ADAMTS4MMP13ADAMTS5ERBB2ERBB4 | |
| SCHEMBL18151710 | 0.89 | ADAMTS4 (0.45) | ADAMTS4MMP13ADAMTS5ERBB2ERBB4 | |
| SCHEMBL18151924 | 0.86 | ADAMTS4 (0.49) | ADAMTS4MMP13ADAMTS5BCL2L1MCL1 | |
| SCHEMBL18152036 | 0.84 | ADAMTS4 (0.48) | ADAMTS4MMP13ADAMTS5PTGESBCL2L1 | |
| SCHEMBL18174017 | 0.79 | CTSV (0.46) | ADAMTS4MMP13ADAMTS5PTGESMCL1 | |
| SCHEMBL18152276 | 0.78 | ACLY (0.47) | ADAMTS4MMP13ADAMTS5BCL2L1MCL1 | |
| SCHEMBL18174100 | 0.78 | PTGES (0.41) | ERBB2ERBB4PTGESMAPT | |
| SCHEMBL18151705 | 0.78 | EGFR (0.45) | PTGESMCL1MEN1LMNAKMT2A | |
| SCHEMBL18152209 | 0.78 | KDM4E (0.44) | ADAMTS4MMP13ADAMTS5ERBB2ERBB4 | |
| SCHEMBL18152073 | 0.77 | EGFR (0.44) | PTGESMEN1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3285583-B1 | SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF | UNIV MICHIGAN REGENTS (US) | 2021-03-17 | — | — | EP | disclosed |