Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 8/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GLS | O94925 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27783043 | 0.88 | RNF4 (0.58) | NPC1SMN1; SMN2RAB9AKDM4EMEN1 | |
| SCHEMBL27804582 | 0.86 | KDM4E (0.74) | SMN1; SMN2RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL19538742 | 0.86 | HDAC1 (0.72) | NPC1SMN1; SMN2RAB9AKDM4EMEN1 | |
| SCHEMBL19520513 | 0.86 | HDAC1 (0.70) | NPC1SMN1; SMN2RAB9AKDM4ECSNK2A2 | |
| SCHEMBL12988751 | 0.85 | HDAC1 (0.60) | NPC1SMN1; SMN2RAB9AHPGDHDAC3 | |
| SCHEMBL17713918 | 0.85 | HDAC1 (0.66) | NPC1SMN1; SMN2RAB9AKDM4EMEN1 | |
| SCHEMBL14954988 | 0.84 | NPC1 (0.63) | NPC1SMN1; SMN2RAB9ATSHRKDM4E | |
| SCHEMBL14962997 | 0.84 | KDM4E (0.76) | NPC1SMN1; SMN2RAB9ATSHRKDM4E | |
| SCHEMBL7929987 | 0.84 | NPC1 (0.63) | NPC1SMN1; SMN2RAB9ATSHRKDM4E | |
| SCHEMBL27804580 | 0.84 | HDAC1 (0.68) | NPC1SMN1; SMN2RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116354962-B | 12-Nitrogen substituted matric acid ester derivative, preparation method and application thereof | 广西大学 | 2025-01-07 | — | — | CN | claimed |
| CN-116354962-A | 12-nitrogen substituted matric acid ester derivative, preparation method and application thereof | 广西大学 | 2023-06-30 | — | — | CN | claimed |
| US-20160152635-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2016-06-02 | — | — | US | claimed |
| CN-102395273-A | Thienopyridine derivatives for the treatment and prevention of dengue virus infection | SIGA TECHNOLOGIES INC | 2012-03-28 | — | — | CN | claimed |
| US-20120022046-A1 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-01-26 | — | — | US | claimed |
| CN-116354962-B | 12-Nitrogen substituted matric acid ester derivative, preparation method and application thereof | 广西大学 | 2025-01-07 | — | — | CN | disclosed |
| CN-116354962-A | 12-nitrogen substituted matric acid ester derivative, preparation method and application thereof | 广西大学 | 2023-06-30 | — | — | CN | disclosed |
| US-10730865-B2 | Compounds for modulating aquaporins | APOGLYX AB (SE) | 2020-08-04 | — | — | US | disclosed |
| US-10730865-B2 | Compounds for modulating aquaporins | APOGLYX AB (SE) | 2020-08-04 | — | — | US | disclosed |
| US-20190127360-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2019-05-02 | — | — | US | disclosed |
| US-20190127360-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2019-05-02 | — | — | US | disclosed |
| WO-2017186893-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2017-11-02 | — | — | WO | disclosed |
| CN-102395273-A | Thienopyridine derivatives for the treatment and prevention of dengue virus infection | SIGA TECHNOLOGIES INC | 2012-03-28 | — | — | CN | disclosed |
| CN-101723943-B | 1,3, 4-thiadiazolyl fluorouracil compounds and preparation method and application thereof | NANJING TECH UNIVERSITY (CN) | 2012-02-01 | — | — | CN | disclosed |
| US-20120022046-A1 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-01-26 | — | — | US | disclosed |
| US-20120022046-A1 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-01-26 | — | — | US | disclosed |
| US-20120022046-A1 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-01-26 | — | — | US | disclosed |
| EP-2400845-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | Siga Technologies, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099166-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| CN-101723943-A | 1,3, 4-thiadiazolyl fluorouracil compounds and preparation method and application thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2010-06-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022046-A1 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections | TTPA, TPMT, SLC19A2 | NPC1 2091/4885SMN1; SMN2 993/4885RAB9A 1654/4885 |
| US-10730865-B2 | Compounds for modulating aquaporins | AQP1, AQP4, AQP3 | NPC1 96/4885SMN1; SMN2 4791/4885RAB9A 386/4885 |
| US-20190127360-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | AQP1, AQP4, AQP3 | NPC1 96/4885SMN1; SMN2 4791/4885RAB9A 386/4885 |
| US-20160152635-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | TTPA, TPMT, SLC19A2 | NPC1 2091/4885SMN1; SMN2 993/4885RAB9A 1654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.