Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23107347 | 1.00 | MAP4K1 (0.32) | MAP4K1ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL23106882 | 1.00 | MAP4K1 (0.32) | MAP4K1ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL23089487 | 0.80 | ALDH1A1 (0.34) | MAP4K1ALDH1A1LMNAKMT2A | |
| SCHEMBL24493046 | 0.77 | NOS3 (0.33) | — | |
| SCHEMBL23103528 | 0.77 | CPB2 (0.38) | MAP4K1ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL23114542 | 0.77 | MAP4K1 (0.32) | MAP4K1LMNAMAPTTP53MEN1 | |
| SCHEMBL23108875 | 0.77 | LMNA (0.32) | MAP4K1LMNAMAPTTP53 | |
| SCHEMBL23108633 | 0.77 | LMNA (0.32) | MAP4K1LMNAMAPTTP53 | |
| SCHEMBL23133738 | 0.77 | CPB2 (0.38) | MAP4K1ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL24493449 | 0.76 | PDE10A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |
| WO-2021050964-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2021-03-18 | — | — | WO | disclosed |