Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | FBP1 | P09467 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | P4HB | P07237 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9480693 | 0.93 | ALDH1A1 (0.53) | ALDH1A1KDM4EFBP1L3MBTL1TDP1 | |
| SCHEMBL5202399 | 0.91 | FBP1 (0.53) | ALDH1A1KDM4EFBP1L3MBTL1TDP1 | |
| SCHEMBL5202408 | 0.91 | FBP1 (0.53) | ALDH1A1KDM4EFBP1L3MBTL1TDP1 | |
| SCHEMBL2439471 | 0.85 | FBP1 (0.57) | ALDH1A1KDM4EFBP1L3MBTL1PKM | |
| SCHEMBL2439472 | 0.85 | FBP1 (0.57) | ALDH1A1KDM4EFBP1L3MBTL1PKM | |
| SCHEMBL8028788 | 0.84 | KMT2A (0.47) | ALDH1A1KDM4EFBP1L3MBTL1TDP1 | |
| SCHEMBL8028786 | 0.84 | KMT2A (0.47) | ALDH1A1KDM4EFBP1L3MBTL1TDP1 | |
| SCHEMBL9315389 | 0.83 | ALDH1A1 (0.82) | ALDH1A1KDM4EL3MBTL1TDP1GLA | |
| SCHEMBL230881 | 0.83 | MEN1 (0.56) | ALDH1A1KDM4EFBP1L3MBTL1TDP1 | |
| SCHEMBL230880 | 0.83 | MEN1 (0.56) | ALDH1A1KDM4EFBP1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440324-B1 | Substituted beta-diketones and their use in the treatment of inflammatory bowel disease | ORION YHTYMAE OY (FI) | 2000-04-12 | — | — | EP | claimed |
| EP-0357403-B1 | Substituted beta-diketones | ORION YHTYMAE OY (FI) | 1994-12-14 | — | — | EP | claimed |
| US-5292771-A | Treating inflammatory bowel disease | ORION-YHTYMA OY (FI) | 1994-03-08 | — | — | US | claimed |
| US-5288750-A | Antiulcer agents for gastrointestinal disorders | ORION-YHTYMA OY (FI) | 1994-02-22 | — | — | US | claimed |
| EP-0440324-A2 | Substituted beta-diketones and their use | ORION-YHTYMÀ OY (FI) | 1991-08-07 | — | — | EP | claimed |
| WO-1990002724-A1 | SUBSTITUTED β-DIKETONES | Orion-Yhtymä Oy (FI) | 1990-03-22 | — | — | WO | claimed |
| EP-0357403-A2 | Substituted beta-diketones | ORION-YHTYMÀ OY (FI) | 1990-03-07 | — | — | EP | claimed |
| EP-2035419-B1 | 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS | BAYER IP GMBH (DE) | 2016-06-22 | — | — | EP | disclosed |
| EP-2035419-B1 | 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS | BAYER IP GMBH (DE) | 2016-06-22 | — | — | EP | disclosed |
| US-9359362-B2 | Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-06-07 | — | — | US | disclosed |
| US-20140038988-A1 | TRIAZOLO AND TETRAZOLO PYRIMIDINE DERIVATIVES AS HNE INHIBITORS FOR TREATING COPD | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-06 | — | — | US | disclosed |
| US-8569314-B2 | Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-10-29 | — | — | US | disclosed |
| US-8404709-B2 | Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| EP-0357403-B1 | Substituted beta-diketones | ORION YHTYMAE OY (FI) | 1994-12-14 | — | — | EP | disclosed |
| US-5292771-A | Treating inflammatory bowel disease | ORION-YHTYMA OY (FI) | 1994-03-08 | — | — | US | disclosed |
| US-5288750-A | Antiulcer agents for gastrointestinal disorders | ORION-YHTYMA OY (FI) | 1994-02-22 | — | — | US | disclosed |
| US-5185370-A | Substituted β-diketones and their use | ORION-YHTYMA OY (FI) | 1993-02-09 | — | — | US | disclosed |
| EP-0440324-A2 | Substituted beta-diketones and their use | ORION-YHTYMÀ OY (FI) | 1991-08-07 | — | — | EP | disclosed |
| WO-1990002724-A1 | SUBSTITUTED β-DIKETONES | Orion-Yhtymä Oy (FI) | 1990-03-22 | — | — | WO | disclosed |
| EP-0357403-A2 | Substituted beta-diketones | ORION-YHTYMÀ OY (FI) | 1990-03-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038988-A1 | TRIAZOLO AND TETRAZOLO PYRIMIDINE DERIVATIVES AS HNE INHIBITORS FOR TREATING COPD | KEAP1, NOX4, NOX5 | ALDH1A1 197/4885KDM4E 4248/4885FBP1 1905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.