Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25106760 | 0.79 | MITF (0.41) | GRK6KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL1979899 | 0.77 | CSNK1D (0.49) | CSNK1DKDM4ENPC1RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL11773323 | 0.76 | CSNK1D (0.48) | CSNK1DKDM4ENPC1RAB9ALMNA | |
| SCHEMBL23108117 | 0.74 | CSNK1D (0.49) | CSNK1DKDM4ENPC1RAB9ALMNA | |
| SCHEMBL7478527 | 0.72 | GRK6 (0.41) | GRK6KDM4ENPC1RAB9ALMNA | |
| SCHEMBL863014 | 0.71 | GRK6 (0.44) | GRK6CSNK1DKDM4ENPC1RAB9A | |
| SCHEMBL31539359 | 0.69 | IDO1 (0.44) | CSNK1DKDM4ENPC1RAB9ALMNA | |
| SCHEMBL10686403 | 0.69 | IDO1 (0.35) | CSNK1DKDM4ENPC1RAB9ALMNA | |
| SCHEMBL278381 | 0.69 | GRK6 (0.42) | GRK6CSNK1DKDM4ENPC1RAB9A | |
| SCHEMBL1407224 | 0.69 | LMNA (0.60) | KDM4ENPC1RAB9ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230063457-A1 | DNA-PK INHIBITING COMPOUNDS | PROVINCIAL HEALTH SERVICES AUTHORITY (CA) | 2023-03-02 | — | — | US | disclosed |
| WO-2021050059-A1 | DNA-PK INHIBITING COMPOUNDS | PROVINCIAL HEALTH SERVICES AUTHORITY (CA) | 2021-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230063457-A1 | DNA-PK INHIBITING COMPOUNDS | DCK, POLK, ERCC2 | GRK6 647/4885CSNK1D 660/4885KDM4E 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.