Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | PNLIP | P16233 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375267 | 0.85 | MAPT (0.42) | CYP1A2CYP2C9CYP2C19KMT2AALDH1A1 | |
| SCHEMBL231819 | 0.85 | DPP4 (0.43) | DPP4LTA4HTSHRCYP1A2CYP3A4 | |
| SCHEMBL984802 | 0.82 | SLC6A4 (0.47) | CYP1A2CYP2C9CYP2C19LMNAMRGPRX4 | |
| SCHEMBL1451604 | 0.82 | LTA4H (0.46) | LTA4HTSHRCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5583577 | 0.81 | HTR2A (0.42) | LMNAKMT2AALDH1A1NPSR1POLB | |
| SCHEMBL2329802 | 0.81 | SLC6A4 (0.39) | LMNAALDH1A1L3MBTL1HTR2ASLC6A4 | |
| SCHEMBL5583613 | 0.81 | POLB (0.41) | LTA4HCYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL1446587 | 0.80 | ALDH1A1 (0.49) | LTA4HLMNAKMT2AALDH1A1NPSR1 | |
| SCHEMBL2333939 | 0.80 | EGFR (0.39) | KMT2AALDH1A1MAPTMRGPRX4HTR2A | |
| SCHEMBL21630261 | 0.78 | FFAR1 (0.42) | LMNAKMT2AMAPTTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179161-A1 | Pyrazolopyrimidine compounds and their use in medicine | VERNALIS (CAMBRIDGE) LIMITED. (GB) | 2007-08-02 | — | — | US | claimed |
| US-7183278-B1 | Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component | MEIJI SEIKA KAISHA, LTD. (JP) | 2007-02-27 | — | — | US | claimed |
| EP-1608652-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE IN MEDICINE | Vernalis (Cambridge) Limited (GB) | 2005-12-28 | — | — | EP | claimed |
| CN-1213658-C | Pyridinecarboxamide derivative and pest control agent containing same as active ingredient | MEIJI SEIKA KAISHA (JP) | 2005-08-10 | — | — | CN | claimed |
| WO-2004087707-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE IN MEDICINE | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2004-10-14 | — | — | WO | claimed |
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | claimed |
| CN-1329596-A | Pyridinecarboxamide derivative and pest control agent containing same as active ingredient | MEIJI SEIKA KAISHA (JP) | 2002-01-02 | — | — | CN | claimed |
| EP-1134214-A1 | PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MEIJI SEIKA KAISHA LTD. (JP) | 2001-09-19 | — | — | EP | claimed |
| US-5821240-A | ENZYME INHIBITORS, SIGNAL INHIBITORS FOR ANTIINFLAMMATORY AGENTS, ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS AND HORMONE INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1998-10-13 | — | — | US | claimed |
| EP-0060640-B1 | 5,6,7-TRINOR-4,8-INTER-M-PHENYLENE PGI DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TORAY INDUSTRIES, INC. (JP) | 1985-11-13 | — | — | EP | claimed |
| US-10316017-B2 | COT modulators and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2019-06-11 | — | — | US | disclosed |
| WO-2018103058-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-14 | — | — | WO | disclosed |
| WO-2018103060-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-14 | — | — | WO | disclosed |
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-12-21 | — | — | US | disclosed |
| US-8791102-B2 | Acetanilide sphingosine-1-phosphate receptor antagonists | EXELIXIS, INC. (US) | 2014-07-29 | — | — | US | disclosed |
| EP-0024943-B1 | 5,6,7-TRINOR-4,8-INTER-M-PHENYLENE PGI2 DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TORAY INDUSTRIES, INC. (JP) | 1983-08-17 | — | — | EP | disclosed |
| EP-0061426-A1 | Process for colouring highly molecular organic material and polycyclic pigments | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | disclosed |
| EP-0060640-A1 | 5,6,7-Trinor-4,8-inter-m-phenylene PGI derivatives and pharmaceutical compositions containing them | TORAY INDUSTRIES, INC. (JP) | 1982-09-22 | — | — | EP | disclosed |
| US-4301164-A | FOR USE AS ANTIULCER AGENTS, HYPOTENSIVE AGENTS, ANTITHROMBOSIC AGENTS | TORAY INDUSTRIES, INC. (JP) | 1981-11-17 | — | — | US | disclosed |
| EP-0024943-A1 | 5,6,7-Trinor-4,8-inter-m-phenylene PGI2 derivatives and pharmaceutical compositions containing them | TORAY INDUSTRIES, INC. (JP) | 1981-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | DPP4 3764/4885LTA4H 3109/4885TSHR 11/4885 |
| US-10316017-B2 | COT modulators and methods of use thereof | BRDT, THRB, HCCS | DPP4 3764/4885LTA4H 3109/4885TSHR 11/4885 |
| US-20070179161-A1 | Pyrazolopyrimidine compounds and their use in medicine | ROS1, ALK, NOX1 | DPP4 2146/4885LTA4H 3072/4885TSHR 1076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.