Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20702680 | 0.84 | GSK3B (0.45) | GSK3BPTPN1 | |
| SCHEMBL1849394 | 0.83 | CES2 (0.56) | GSK3BPTPN1CES2CES1 | |
| SCHEMBL18356296 | 0.81 | PTPN1 (0.52) | GSK3BPTPN1CES2CES1 | |
| SCHEMBL16600782 | 0.81 | PTPN1 (0.52) | GSK3BPTPN1CES2CES1 | |
| SCHEMBL20819692 | 0.79 | HDAC1 (0.52) | GSK3BPTPN1CES2CES1 | |
| SCHEMBL3973133 | 0.79 | GSK3B (0.55) | GSK3BPTPN1 | |
| SCHEMBL29499477 | 0.79 | GSK3B (0.55) | GSK3BPTPN1 | |
| SCHEMBL5050111 | 0.78 | GSK3B (0.54) | GSK3BPTPN1 | |
| SCHEMBL6543881 | 0.77 | GSK3B (0.59) | GSK3BPTPN1 | |
| SCHEMBL1852011 | 0.76 | GSK3B (0.52) | GSK3BPTPN1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324865-A1 | SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2022-10-13 | — | — | US | disclosed |
| EP-3793559-A1 | SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2021-03-24 | — | — | EP | disclosed |
| CN-112469412-A | Substituted dihydropyrazolopyrazine carboxamide derivatives | 拜耳公司 | 2021-03-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324865-A1 | SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES | QDPR, SIRT5, PDXK | GSK3B 3707/4885PTPN1 2816/4885CES2 3081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.