Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21288599 | 0.87 | KMT2A (0.64) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL28858596 | 0.85 | PTPN11 (0.57) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL27149873 | 0.84 | L3MBTL1 (0.55) | NPC1RAB9AMEN1KMT2APARP1 | |
| SCHEMBL2311164 | 0.82 | KDM4E (0.59) | KDM4ESCN9AABL1 | |
| SCHEMBL184785 | 0.82 | KDM4E (0.58) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL29365729 | 0.81 | PTPN11 (0.68) | KDM4EMAPTMEN1HTTKMT2A | |
| SCHEMBL69025 | 0.81 | PTPN11 (0.68) | KDM4EMAPTMEN1HTTKMT2A | |
| SCHEMBL22192208 | 0.81 | PTPN11 (0.65) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL1856468 | 0.80 | KDM4E (0.70) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL8732524 | 0.79 | PTPN11 (0.66) | KDM4EMAPTMEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846366-B1 | NORVALINE DERIVATIVE AND METHOD FOR PREPARATION THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-03 | — | — | EP | disclosed |
| US-7718703-B2 | Norvaline derivative and method for preparation thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20080076769-A1 | Norvaline Derivative and Method for Preparation Thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-03-27 | — | — | US | disclosed |
| EP-1846366-A1 | NORVALINE DERIVATIVE AND METHOD FOR PREPARATION THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006080477-A1 | NORVALINE DERIVATIVE AND METHOD FOR PREPARATION THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076769-A1 | Norvaline Derivative and Method for Preparation Thereof | SLC38A7, SLC7A1, SLC6A7 | KDM4E 4063/4885MAPT 3288/4885NPC1 293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.