Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355038 | 0.81 | KMT2A (0.65) | KMT2AMAOBMEN1ALDH1A1PRSS1 | |
| SCHEMBL6856717 | 0.78 | KMT2A (0.76) | KMT2AMAOBMEN1ALDH1A1PRSS1 | |
| SCHEMBL14331174 | 0.78 | KMT2A (0.64) | KMT2AMAOBMEN1PRSS1THRA | |
| SCHEMBL2553169 | 0.78 | KMT2A (0.63) | KMT2AMAOBPOLBMEN1ALDH1A1 | |
| SCHEMBL7273154 | 0.77 | THRA (0.55) | KDM4EPOLBHPGDHSD17B10PRSS1 | |
| SCHEMBL26490528 | 0.77 | POLB (0.40) | KMT2AKDM4EPOLBMEN1HTT | |
| SCHEMBL7954068 | 0.76 | MCL1 (0.52) | KMT2AKDM4EPOLBMEN1ALDH1A1 | |
| SCHEMBL7953867 | 0.76 | MCL1 (0.52) | KMT2AKDM4EPOLBMEN1ALDH1A1 | |
| SCHEMBL1545288 | 0.76 | KMT2A (0.64) | KMT2AMAOBMEN1PRSS1HTT | |
| SCHEMBL6973871 | 0.76 | KMT2A (0.64) | KMT2AMAOBMEN1ALDH1A1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230137943-A1 | PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS | THE UNIVERSITY OF CHICAGO | 2023-05-04 | — | — | US | disclosed |
| EP-4031550-A1 | PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS | The University of Chicago (US) | 2022-07-27 | — | — | EP | disclosed |
| CN-114728970-A | Optical proximity analysis of protein-protein interactions in cells | 芝加哥大学 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021055960-A1 | PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS | THE UNIVERSITY OF CHICAGO (US) | 2021-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230137943-A1 | PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS | PPIA, S100A4, S100A6 | KMT2A 3560/4885MAOB 3324/4885KDM4E 3501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.