Antipain

Antipain

SCHEMBL23132673

CC(C)C(NC(=O)[C@H](CCCNC(=N)N)NC(=O)NC(Cc1ccccc1)C(=O)O)C(=O)NC(C=O)CCCNC(=N)N

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 1/20 0.74
▸ CTSK P43235 3/20 0.52
▸ CTSB P07858 1/20 0.45
▸ NPY4R P50391 6/20 0.43
▸ NPY1R P25929 4/20 0.43
▸ NPY2R P49146 3/20 0.43
▸ NPY5R Q15761 3/20 0.43
▸ KISS1R Q969F8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Antipain SCHEMBL18328611 1.00 SMN1; SMN2 (0.74) SMN1; SMN2CTSKCTSBNPY4RNPY1R
Antipain SCHEMBL14038024 1.00 SMN1; SMN2 (0.74) SMN1; SMN2CTSKCTSBNPY4RNPY1R
Antipain SCHEMBL3280675 1.00 SMN1; SMN2 (0.74) SMN1; SMN2CTSKCTSBNPY4RNPY1R
Antipain SCHEMBL5966873 1.00 SMN1; SMN2 (0.74) SMN1; SMN2CTSKCTSBNPY4RNPY1R
Antipain SCHEMBL642095 1.00 SMN1; SMN2 (0.74) SMN1; SMN2CTSKCTSBNPY4RNPY1R
SCHEMBL26807763 0.97 SMN1; SMN2 (0.69) SMN1; SMN2CTSKCTSBNPY4RNPY1R
SCHEMBL17364033 0.97 SMN1; SMN2 (0.69) SMN1; SMN2CTSKCTSBNPY4RNPY1R
SCHEMBL16328962 0.93 SMN1; SMN2 (0.65) SMN1; SMN2CTSKCTSBNPY4RNPY1R
SCHEMBL17364037 0.93 SMN1; SMN2 (0.64) SMN1; SMN2CTSKNPY4RNPY1RNPY2R
SCHEMBL17364024 0.93 SMN1; SMN2 (0.64) SMN1; SMN2CTSKNPY4RNPY1RNPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210088504-A1 PROTEIN DEGRADATION INDUCING TAG AND USAGE THEREOF TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) 2021-03-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210088504-A1 PROTEIN DEGRADATION INDUCING TAG AND USAGE THEREOF SENP8, SENP6, SENP7 SMN1; SMN2 4697/4885CTSK 914/4885CTSB 624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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