Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 6/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23134692 | 0.95 | PARP1 (0.42) | PARP1HTR4MEN1KMT2ASOS1 | |
| SCHEMBL31722673 | 0.91 | HRH3 (0.40) | PARP1HTR4CHRM4CHRM5ADRA2C | |
| SCHEMBL30963364 | 0.90 | KDM4E (0.41) | PARP1MEN1KMT2ASOS1TLR8 | |
| SCHEMBL31255475 | 0.88 | ALDH1A1 (0.42) | PARP1MEN1KMT2ASOS1TLR8 | |
| SCHEMBL21409284 | 0.87 | NR3C1 (0.42) | MEN1KMT2ATLR8TLR7KDM4E | |
| SCHEMBL23134536 | 0.87 | NR3C1 (0.42) | MEN1KMT2ATLR8TLR7KDM4E | |
| SCHEMBL30963368 | 0.86 | DDB1 (0.42) | PARP1MEN1KMT2ASOS1TLR8 | |
| SCHEMBL21409448 | 0.86 | HSD11B1 (0.42) | MEN1KMT2ATLR8TLR7KDM4E | |
| Hydrochloric Acid SCHEMBL23122705 | 0.85 | HSD11B1 (0.41) | MEN1KMT2ATLR8TLR7KDM4E | |
| Hydrochloric Acid SCHEMBL30008988 | 0.85 | HSD11B1 (0.41) | MEN1KMT2ATLR8TLR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021055295-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-03-25 | — | — | WO | disclosed |