Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLTP | P55058 | 7/20 | 0.51 |
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2318313 | 0.93 | PLTP (0.49) | PLTPCETPDGAT1MEN1KMT2A | |
| SCHEMBL2315529 | 0.90 | DGAT1 (0.56) | PLTPDGAT1MEN1KMT2AKDM4E | |
| SCHEMBL2487506 | 0.90 | PLTP (0.52) | PLTPCETPDGAT1MEN1KMT2A | |
| SCHEMBL2316605 | 0.89 | ADORA1 (0.52) | PLTPDGAT1MEN1KMT2APTGDR2 | |
| SCHEMBL2317599 | 0.89 | PLTP (0.49) | PLTPDGAT1MEN1KMT2AKDM4E | |
| SCHEMBL2314988 | 0.88 | TRPV4 (0.54) | PLTPDGAT1KDM4EHTTPTGDR2 | |
| SCHEMBL2316639 | 0.87 | DGAT1 (0.46) | PLTPDGAT1MEN1KMT2AKDM4E | |
| SCHEMBL2316402 | 0.85 | PLTP (0.51) | PLTPDGAT1MEN1KMT2AKDM4E | |
| SCHEMBL2318436 | 0.85 | PLTP (0.50) | PLTPDGAT1KMT2AKDM4EPTGDR2 | |
| SCHEMBL2313698 | 0.85 | PLTP (0.49) | PLTPDGAT1KMT2AKDM4EPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349484-A2 | HETEROARYL DERIVATIVES AS DGAT1 INHIBITORS | Novartis AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010007046-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-01-21 | — | — | WO | disclosed |