Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.56 |
| ▸ | PLTP | P55058 | 7/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2313671 | 0.90 | PLTP (0.51) | DGAT1PLTPRORCSCDADORA2A | |
| SCHEMBL2360230 | 0.90 | DGAT1 (0.59) | DGAT1PLTPRORCSCDADORA2A | |
| SCHEMBL2317776 | 0.90 | DGAT1 (0.59) | DGAT1PLTPRORCADORA2AADORA1 | |
| SCHEMBL2318313 | 0.87 | PLTP (0.49) | DGAT1PLTPRORCMAPTLMNA | |
| SCHEMBL2316605 | 0.84 | ADORA1 (0.52) | DGAT1PLTPRORCADORA2AADORA1 | |
| SCHEMBL2317599 | 0.84 | PLTP (0.49) | DGAT1PLTPRORCSCDADORA1 | |
| SCHEMBL2316402 | 0.84 | PLTP (0.51) | DGAT1PLTPRORCADORA2AADORA1 | |
| SCHEMBL2314988 | 0.84 | TRPV4 (0.54) | DGAT1PLTPRORCADORA1KDM4E | |
| SCHEMBL2318436 | 0.83 | PLTP (0.50) | DGAT1PLTPRORCADORA2AADORA1 | |
| SCHEMBL2313698 | 0.83 | PLTP (0.49) | DGAT1PLTPRORCADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349484-A2 | HETEROARYL DERIVATIVES AS DGAT1 INHIBITORS | Novartis AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010007046-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-01-21 | — | — | WO | disclosed |